Background Uncertainty regarding comorbid illness, and ability to tolerate aggressive
therapy has led to minimal enrollment of elderly cancer patients into clinical trials and often …

ContextDespite the importance of diversity of cancer trial participants with regard to race,
ethnicity, age, and sex, there is little recent information about the representation of these …

Purpose To analyze the age-related enrollment of cancer patients onto registration trials of
new drugs or new indications approved by the US Food and Drug Administration from 1995 …

BACKGROUND Aging remains one of the single greatest risk factors for the development of
new breast carcinoma. The aim of the study was to evaluate the relation between biologic …

Background Recently published population-based investigations showed elderly patients to
be underrepresented in clinical trials and less often treated according to the standard …

Background Platinum-based combination chemotherapy is currently recommended as the
standard treatment for patients with advanced non-small-cell lung cancer (NSCLC), but its …

Management of cancer in the elderly population is currently perceived as one of the major
challenges for clinical research in medical oncology. Multidisciplinary evaluation of the …

Purpose To evaluate the outcome of elderly patients with head and neck cancer undergoing
palliative chemotherapy. Patients and Methods We analyzed combined data from two …

Purpose Few interventions have been designed and tested to improve recruitment to clinical
trials in oncology. The multiple factors influencing patients' decisions have made the …

Background: Previous studies report underuse of radiation and chemotherapy in the elderly,
yet few have examined the rates of use (or underuse) of surgery. Using national data, we …