CD1: antigen presentation and T cell function
M Brigl, MB Brenner - Annu. Rev. Immunol., 2004 - annualreviews.org
▪ Abstract This review summarizes the major features of CD1 genes and proteins, the
patterns of intracellular trafficking of CD1 molecules, and how they sample different …
patterns of intracellular trafficking of CD1 molecules, and how they sample different …
[PDF][PDF] To be or not to be NKT: natural killer T cells in the liver
Much of the hepatology literature to date has focused on the adaptive, antigen‐specific
response mediated by classical T‐cell populations in both the protection and pathogenesis …
response mediated by classical T‐cell populations in both the protection and pathogenesis …
The VITAL assay: a versatile fluorometric technique for assessing CTL-and NKT-mediated cytotoxicity against multiple targets in vitro and in vivo
IF Hermans, JD Silk, J Yang, MJ Palmowski… - Journal of …, 2004 - Elsevier
Assessment of cell-mediated toxicity has traditionally been achieved by measuring the
specific activity of enriched effector cell populations against antigen-loaded target cells …
specific activity of enriched effector cell populations against antigen-loaded target cells …
Production of profibrotic cytokines by invariant NKT cells characterizes cirrhosis progression in chronic viral hepatitis
C De Lalla, G Galli, L Aldrighetti, R Romeo… - The Journal of …, 2004 - journals.aai.org
Invariant (inv) NKT cells are a subset of autoreactive lymphocytes that recognize
endogenous lipid ligands presented by CD1d, and are suspected to regulate the host …
endogenous lipid ligands presented by CD1d, and are suspected to regulate the host …
The crystal structure of human CD1b with a bound bacterial glycolipid
T Batuwangala, D Shepherd, SD Gadola… - The Journal of …, 2004 - journals.aai.org
The human MHC class I-like molecule CD1b is distinctive among CD1 alleles in that it is
capable of presenting a set of glycolipid species that show a very broad range of variation in …
capable of presenting a set of glycolipid species that show a very broad range of variation in …
Hepatic CD1d expression in hepatitis C virus infection and recognition by resident proinflammatory CD1d-reactive T cells
E Durante-Mangoni, RJ Wang, A Shaulov… - The Journal of …, 2004 - journals.aai.org
Abstract A subset of CD161+ CD56+/− NKT cells can recognize glycolipids presented by
CD1d and positively or negatively regulate inflammatory responses, including those …
CD1d and positively or negatively regulate inflammatory responses, including those …
The immunoregulatory role of CD1d-restricted natural killer T cells in disease
HJJ Van Der Vliet, JW Molling, BME Von Blomberg… - Clinical …, 2004 - Elsevier
Natural killer T (NKT) cells constitute a T cell subpopulation that shares several
characteristics with NK cells. NKT cells are characterized by a narrow T cell antigen receptor …
characteristics with NK cells. NKT cells are characterized by a narrow T cell antigen receptor …
Recovery of Vα24+ NKT cells after hematopoietic stem cell transplantation
K Haraguchi, T Takahashi, K Hiruma, Y Kanda… - Bone marrow …, 2004 - nature.com
Human Vα24+ natural killer T (NKT) cells have an invariant T-cell receptor-α chain and are
activated in a CD1d-restricted manner. Vα24+ NKT cells are thought to regulate immune …
activated in a CD1d-restricted manner. Vα24+ NKT cells are thought to regulate immune …
Diverse populations of T cells with NK cell receptors accumulate in the human intestine in health and in colorectal cancer
T cells expressing NK cell receptors (NKR) display rapid MHC‐unrestricted cytotoxicity and
potent cytokine secretion and are thought to play roles in immunity against tumors. We have …
potent cytokine secretion and are thought to play roles in immunity against tumors. We have …
Development of innate CD4+ α-chain variable gene segment 24 (Vα24) natural killer T cells in the early human fetal thymus is regulated by IL-7
JK Sandberg, CA Stoddart, F Brilot… - Proceedings of the …, 2004 - National Acad Sciences
Natural killer (NK) T cells are innate CD1d-restricted immune cells involved in regulation of
immune tolerance, tumor immunity, and immunity to infectious pathogens. Human α-chain …
immune tolerance, tumor immunity, and immunity to infectious pathogens. Human α-chain …