Hypoxic pulmonary vasoconstriction: redox regulation of O2-sensitive K+ channels by a mitochondrial O2-sensor in resistance artery smooth muscle cells
Hypoxic pulmonary vasoconstriction (HPV) is a widely-conserved mechanism for matching
ventilation and perfusion that optimizes systemic PO2. HPV is elicited by moderate alveolar …
ventilation and perfusion that optimizes systemic PO2. HPV is elicited by moderate alveolar …
Bi-directional effects of GABAB receptor agonists on the mesolimbic dopamine system
HG Cruz, T Ivanova, ML Lunn, M Stoffel… - Nature …, 2004 - nature.com
The rewarding effect of drugs of abuse is mediated by activation of the mesolimbic
dopamine system, which is inhibited by putative anti-craving compounds. Interestingly …
dopamine system, which is inhibited by putative anti-craving compounds. Interestingly …
O2 sensing in the human ductus arteriosus: redox-sensitive K+ channels are regulated by mitochondria-derived hydrogen peroxide
The ductus arteriosus (DA) is a fetal artery that allows blood ejected from the right ventricle
to bypass the pulmonary circulation in utero. At birth, functional closure of the DA is initiated …
to bypass the pulmonary circulation in utero. At birth, functional closure of the DA is initiated …
[HTML][HTML] Coordination of membrane excitability through a GIRK1 signaling complex in the atria
EN Nikolov, TT Ivanova-Nikolova - Journal of Biological Chemistry, 2004 - ASBMB
Control of heart rate is a complex process that integrates the function of multiple G protein-
coupled receptors and ion channels. Among them, the G protein-regulated inwardly …
coupled receptors and ion channels. Among them, the G protein-regulated inwardly …
Measuring the modulatory effects of RGS proteins on GIRK channels
CA Doupnik, C Jaén, Q Zhang - Methods in enzymology, 2004 - Elsevier
Discovery of “regulators of G-protein signaling”(RGS) as GTPase-activating proteins for
heterotrimeric G proteins has provided a highly sought “missing link,” reconciling past …
heterotrimeric G proteins has provided a highly sought “missing link,” reconciling past …
Rapid desensitization of G protein-gated inwardly rectifying K+ currents is determined by G protein cycle
JL Leaney, A Benians, S Brown… - … of Physiology-Cell …, 2004 - journals.physiology.org
Activation of G protein-gated inwardly rectifying K+ (GIRK) channels, found in the brain,
heart, and endocrine tissue, leads to membrane hyperpolarization that generates neuronal …
heart, and endocrine tissue, leads to membrane hyperpolarization that generates neuronal …
Characterization of functional effects of Z-338, a novel gastroprokinetic agent, on the muscarinic M1, M2, and M3 receptors expressed in Xenopus oocytes
Y Doi, O Murasaki, M Kaibara, Y Uezono… - European journal of …, 2004 - Elsevier
This study characterized the functional effects of a novel gastroprokinetic agent, N-[2-
(diisopropylamino) ethyl]-2-[(2-hydroxy-4, 5-dimethoxybenzoyl) amino]-1, 3-thiazole-4 …
(diisopropylamino) ethyl]-2-[(2-hydroxy-4, 5-dimethoxybenzoyl) amino]-1, 3-thiazole-4 …
DNA encoding a human melanin concentrating hormone receptor (MCH1) and uses thereof
J Salon, T Laz, R Nagorny, A Wilson… - US Patent App. 10 …, 2004 - Google Patents
2003-09-22 Assigned to SYNAPTIC PHARMACEUTICAL CORPORATION reassignment
SYNAPTIC PHARMACEUTICAL CORPORATION ASSIGNMENT OF ASSIGNORS …
SYNAPTIC PHARMACEUTICAL CORPORATION ASSIGNMENT OF ASSIGNORS …
[HTML][HTML] Functional characterization of a small conductance GIRK channel in rat atrial cells
EN Nikolov, TT Ivanova-Nikolova - Biophysical journal, 2004 - cell.com
Abstract Muscarinic K+(K ACh) channels are key determinants of the inhibitory synaptic
transmission in the heart. These channels are heterotetramers consisting of two homologous …
transmission in the heart. These channels are heterotetramers consisting of two homologous …
DNA encoding mammalian neuropeptide FF (NPFF) receptors and uses thereof
CPG Gerald, KA Jones, JA Bonini… - US Patent …, 2004 - Google Patents
Dunham LLP (57) ABSTRACT This invention provides isolated nucleic acids encoding
mammalian NPFF receptors, purified mammalian NPFF receptors, vectors comprising …
mammalian NPFF receptors, purified mammalian NPFF receptors, vectors comprising …