Splenic peripheral B‐cell development and the events regulating this functionally significant
but relatively poorly defined developmental process have become a major focus in recent …

B cells complete maturation after migrating to the periphery, where they transit several
intermediate developmental stages prior to recruitment into the long‐lived primary pool …

We previously showed that type I interferon-induced, Cre-mediated ablation of surface BCR
expression in mature B cells through Ig-heavy chain deletion results in apoptosis of these …

Accumulating evidence indicates that positive selection events mediate differentiation,
lineage commitment, and longevity of B lymphocytes. The BCR plays a central role, dictating …

The random and inherently imprecise process of V (D) J recombination is the foundation for
generation of the B-cell receptor (BCR). Signals must be generated to trigger selective …

In adult mice, the number of B lymphocytes remains constant under homeostatic control, in
spite of the fact that B cells are produced continuously in numbers that largely exceed the …

Discovery and characterization of the tumor necrosis factor (TNF) family member B‐
lymphocyte stimulator (BLyS) has opened a novel chapter in the role of TNF family members …

B cells of varying antigen specificities are consistently present in the unmanipulated
repertoire. These B cells appear to belong to the marginal zone (MZ) and B1 B‐cell subsets …

B cell tolerance or autoimmunity is determined by selective events. Negative selection of self-
reactive B cells is well documented and proven. In contrast, positive selection of …

Although autoantigen-induced negative selection plays an important role in shaping the
mature B-cell repertoire, studies in recent years have suggested that differentiation into any …