Collagens represent up to 40% of the total protein of the vessel wall, forming an insoluble
scaffold which is essential for tissue integrity and which provides a surface for the …

Glycoprotein (GP) VI is a platelet membrane protein with a molecular weight of 62 kDa that
was identified as a physiological collagen receptor from studies of patients deficient in this …

Platelet glycoprotein (GP) VI is a 62-kDa membrane glycoprotein that exists on both human
and murine platelets in a noncovalent complex with the Fc receptor (FcR) γ chain. The …

We report a novel case of gray platelet syndrome (GPS) where a severe deficiency of the
platelet collagen receptor, glycoprotein (GP) VI, accompanies classical symptoms of a low …

Glycoprotein VI is a platelet collagen receptor binding to subendothelial collagen after a
rupture of an atherosclerotic plaque. The GPVI gene is polymorphic with several SNPs and …

Lipoxygenases (LOX) contribute to vascular disease and inflammation through generation of
bioactive lipids, including 12-hydro (pero) xyeicosatetraenoic acid (12-H (P) ETE). The …

Exposure of circulating blood to collagen after vessel injury has been recognized as a
primary event in arterial thrombosis for many years but an understanding of the molecular …

Abstract von Willebrand disease (VWD) type 1 is difficult to diagnose because of bleeding
variability and low heritability of von Willebrand factor (VWF) levels. We compared a …

The last several years have seen an abundance of studies of genetic risk factors for vascular
disease, and platelet glycoprotein (GP) polymorphisms have been a primary focus of this …

Based on the detailed study of the antigens that are recognized by alloantibodies, for
example, polymorphisms on a number of platelet receptors have been identified and …