[HTML][HTML] Mono-unsaturated fatty acids protect against β-cell apoptosis induced by saturated fatty acids, serum withdrawal or cytokine exposure
HJ Welters, M Tadayyon, JHB Scarpello, SA Smith… - FEBS letters, 2004 - Elsevier
Long-chain saturated fatty acids are cytotoxic to pancreatic β-cells while shorter-chain
saturated and long-chain unsaturated molecules are better tolerated. Mono-unsaturated fatty …
saturated and long-chain unsaturated molecules are better tolerated. Mono-unsaturated fatty …
N-terminal His7-modification of glucagon-like peptide-1 (7-36) amide generates dipeptidyl peptidase IV-stable analogues with potent antihyperglycaemic activity
Abstract Glucagon-like peptide-1 (7–36) amide (GLP-1) possesses several unique and
beneficial effects for the potential treatment of type 2 diabetes. However, the rapid …
beneficial effects for the potential treatment of type 2 diabetes. However, the rapid …
Comparative effects of GLP-1 and GIP on cAMP production, insulin secretion, and in vivo antidiabetic actions following substitution of Ala8/Ala2 with 2-aminobutyric …
The two major incretin hormones, glucagon-like peptide-1 (GLP-1), and glucose-dependent
insulinotropic polypeptide (GIP), are currently being considered as prospective drug …
insulinotropic polypeptide (GIP), are currently being considered as prospective drug …
[PDF][PDF] Brevinin-1 and multiple insulin-releasing peptides in the skin of the frog Rana palustris
YHA Abdel-Wahab - Journal of endocrinology, 2004 - Citeseer
Few studies have comprehensively examined amphibian granular gland secretions for
novel insulinotropic peptides. This study involved isolation and characterisation of …
novel insulinotropic peptides. This study involved isolation and characterisation of …
Degradation, receptor binding, insulin secreting and antihyperglycaemic actions of palmitate-derivatised native and Ala8-substituted GLP-1 analogues
The hormone glucagon-like peptide-1 (736) amide (GLP-1) is released in response to
ingested nutrients and acts to promote glucose-dependent insulin secretion ensuring …
ingested nutrients and acts to promote glucose-dependent insulin secretion ensuring …
Time-correlation between membrane depolarization and intracellular calcium in insulin secreting BRIN-BD11 cells: studies using FLIPR
JC Miguel, S Patterson, YHA Abdel-Wahab… - Cell Calcium, 2004 - Elsevier
Cytoplasmic Ca2+ ([Ca2+] i) and membrane potential changes were measured in clonal
pancreatic beta cells using a fluorimetric imaging plate reader (FLIPR). KCl (30mM) …
pancreatic beta cells using a fluorimetric imaging plate reader (FLIPR). KCl (30mM) …
Skin secretion of the toad Bombina variegata contains multiple insulin-releasing peptides including bombesin and entirely novel insulinotropic structures
Skin secretions of the toad Bombina variegata were evaluated for the isolation and
characterisation of insulinotropic peptides. Crude secretions obtained from young adult …
characterisation of insulinotropic peptides. Crude secretions obtained from young adult …
DNA damage and cytotoxicity in pancreatic β-cells expressing human CYP2E1
DJL Murdock, YA Barnett, CR Barnett - Biochemical pharmacology, 2004 - Elsevier
Epidemiological studies have identified nitrosamines as a risk factor for Type I (insulin
dependent) diabetes mellitus. These compounds require bioactivation by cytochrome P450 …
dependent) diabetes mellitus. These compounds require bioactivation by cytochrome P450 …
Expression and functional activity of PPARγ in pancreatic β cells
HJ Welters, SC McBain, M Tadayyon… - British journal of …, 2004 - Wiley Online Library
Rosiglitazone is an agonist of peroxisome proliferator activated receptor‐γ (PPARγ) and
ameliorates insulin resistance in type II diabetes. In addition, it may also promote increased …
ameliorates insulin resistance in type II diabetes. In addition, it may also promote increased …
Isolation and characterisation of an unexpected class of insulinotropic peptides in the skin of the frog Agalychnis litodryas
Skin secretions of the frog Agalychnis litodryas were evaluated for the isolation and
characterisation of novel insulinotropic peptides. Crude secretions obtained from young …
characterisation of novel insulinotropic peptides. Crude secretions obtained from young …