Although induction of apoptosis (cell death mediated by caspases) determines response to
cancer therapy, this approach is limited by lack of selectivity in available apoptosis-inducing …

Protein kinase C (PKC) is a family of serine/threonine kinases that regulates a variety of cell
functions including proliferation, gene expression, cell cycle, differentiation, cytoskeletal …

Therapy for patients with advanced thyroid carcinoma is limited. Clinical and in vitro studies
suggest that some patients with advanced thyroid cancer may respond to therapy with …

De-differentiated thyroid carcinoma is characterized by loss of thyroid-specific functions and
properties. The therapeutic options for this type of thyroid cancer are limited and generally …

AIMS: Radio-iodine is effective in treating metastatic differentiated thyroid cancers. In 20% of
cases, however, these tumours fail to take up radio-iodine, and treatment options are then …

Results Although thyroglobulin levels increased in four of the five patients after 3 months of
treatment with rosiglitazone, the 131 I scan remained negative in four patients and became …

Retinoid X receptors (RXRs) are ligand-inducible transcription factors that belong to the
superfamily of nuclear hormone receptors. Because RXRs heterodimerize with thyroid …

Objectives This was a retrospective study to assess the efficacy and morbidity of high activity
131 I therapy in patients with advanced differentiated thyroid carcinoma. Methods From …

Objective Disturbed expression of retinoic acid (RA) receptors (RAR/RXR) contributes to the
pathogenesis and tumor progression of epithelial carcinomas. Design To examine whether …

The sodium-iodide symporter (NIS) is an intrinsic plasma membrane protein that mediates
active transport of iodide in the thyroid gland and several other extra-thyroidal tissues. This …