A surprisingly large proportion of new drug candidates emerging from drug discovery
programmes are water insoluble, and therefore poorly bioavailable, leading to abandoned …

Poor water solubility is an industry wide issue, especially for pharmaceutical scientists in
drug discovery and drug development. In recent years, nanoparticle engineering processes …

The objective of this study was to assess the contributions of surfactant-mediated solubility
and micellar diffusivity on the ability of surfactant to enhance drug dissolution. The following …

Presently, the Caco-2 cell culture model is widely used during drug discovery and
development as a predictive tool for the oral absorption of drug candidates. For transport …

Different formulation approaches were evaluated to ensure that the formulation of a poorly
water soluble compound chosen during early development achieves optimum …

When dissolution testing is used to forecast the in vivo performance of a drug, it is critical that
the in vitro test mimic the conditions in vivo as closely as possible. A team of researchers, led …

This paper describes a means to predict the absorbability of poorly water-soluble drugs in
humans based on rat intestinal permeability assessed by the in vitro Ussing-type chamber …

In this study, we attempted to improve the oral absorption of ceftriaxone (CTX) by using an
absorption carrier and the CTX complex together. After the CTX-Ca-carrageenan gel …

The purpose of the present study was to examine the relevancy of the high throughput
solubility assay and permeability assay to the biopharmaceutics classification system (BCS) …

Bioequivalence of drug formulations plays an important role in drug development. Recently,
the Biopharmaceutical Classification System (BCS) has been implemented for the purpose …