Extensive work in the last 10 years has suggested that heat shock proteins (HSPs) may be
potent activators of the innate immune system. It has been reported that Hsp60, Hsp70 …

Cardiovascular diseases are the leading cause of morbidity and mortality in Western
countries. Atherosclerosis, the background for many cardiovascular diseases, is …

Toll‐like receptor 2 (TLR2) has been shown to recognize several classes of pathogen‐
associated molecular patterns including peptidoglycan (PG). However, studies linking PG …

Activated spinal glial cells have been strongly implicated in the development and
maintenance of persistent pain states following a variety of stimuli including traumatic nerve …

4‐Methyl‐N 1‐(3‐phenyl‐propyl)‐benzene‐1, 2‐diamine (JSH‐23) is a novel chemically
synthetic compound. The aromatic diamine JSH‐23 compound exhibited inhibitory effect …

In addition to serving as molecular chaperones, heat shock proteins (HSPs) have been
implicated in autoimmune diseases, antigen presentation and tumor immunity. Extensive …

Interleukin-1 is a key inflammatory cytokine that mediates its effects through a type I receptor
and a receptor accessory protein. These two molecules are members of a wider family of …

Cytokine‐driven inflammation and tissue destruction is a common theme of chronic
inflammatory diseases such as rheumatoid arthritis, Crohn's disease, ulcerative colitis …

The family of Toll‐like receptors (TLRs) initiates an innate immune response after
recognition of pathogen‐associated molecular patterns (PAMPs). Evidence is accumulating …

Endothelial cells are the primary targets of circulating immune and inflammatory mediators.
We hypothesize that interleukin-18, a proinflammatory cytokine, induces endothelial cell …