G-protein-coupled receptors (GPCR) are involved in directly and indirectly controlling an
extraordinary variety of physiological functions. Their key roles in cellular communication …

Kinins, which are produced by the action of kallikrein enzymes, are blood-derived local-
acting peptides that have broad effects mediated by two related G-protein-coupled receptors …

Kinins are a family of peptides implicated in several pathophysiological events. Most of their
effects are likely mediated by the activation of two G‐protein‐coupled receptors: B1 and B2 …

Several studies have now clearly established the ability of LPS to induce bradykinin B 1
receptor up-regulation in vivo and the functional relevance of this up-regulation for the …

The administration of bradykinin may attenuate ischemia and reperfusion (I/R) injury by
acting on B 2 Rs. Blockade of B 2 R has also been shown to ameliorate lesions associated …

The biochemical and pharmacological properties of a novel non-peptide antagonist of the
bradykinin (BK) B1 receptor, SSR240612 [(2 R)-2-[((3 R)-3-(1, 3-benzodioxol-5-yl)-3-{[(6 …

The role of endogenous kinins and their receptors in diabetes mellitus is being confirmed
with the recent developments of molecular and genetic animal models. Compelling …

Bradykinin B1 receptor antagonists embody a potentially novel approach for the treatment of
chronic pain and inflammation. A series of 2, 3-diaminopyridine B1 antagonists was …

B1 bradykinin receptor (B1R) induction is critical in the adaptation of the kinin-mediated
inflammatory response from a B2 bradykinin receptor (B2R) subtype to a B1R subtype that …

The tissue sclerosis found in epilepsy of limbic origin is characterized by shrunken gliotic
hippocampus, granule cell loss in the dentate gyrus and extensive pyramidal cell loss in …