The p53 tumor suppressor protein exerts its growth inhibitory activity by activating and
interacting with diverse signaling pathways. As a downstream target, p53 protein is …

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Objective: If dedifferentiated chondrocytes could be induced to redifferentiate in vitro, then
we might thereby be furnished with a population of phenotypically stable cells for autologous …

Targeting signaling pathways in osteoarthritis did not seem feasible a few years ago
because of the complexity of the multiple intracellular pathways, mainly physiologic, defined …

Although regulation of chondrogenesis and cartilage development by Wnt signaling is well
established, the function of Wnt in the maintenance and destruction of cartilage remains …

Osteoarthritis (OA) is a debilitating, progressive disease of diarthrodial joints associated with
the aging process. With the exception of anti-inflammatory corticosteroids and nonsteroidal …

Survivin is expressed in most tumor cells and has been associated with both anti-apoptosis
and mitotic progression. However, the mechanism of regulation of the survivin expression …

The cyclopentenone prostaglandin (PG) J2 is formed within the cyclopentenone ring of the
endogenous prostaglandin PG D2 by a nonenzymatic reaction. The PG J family is involved …

In a population of cells undergoing oxidative stress, an individual cell either succumbs to
apoptotic cell death or maintains homeostasis and survives. Exposure of PC-12-D 2 R cells …

OBJECTIVE: The prevalence of osteoarthritis (OA) is increased in aged individuals and a
direct correlation between chondrocyte apoptosis and cartilage degradation secondary to …