Patients with the metabolic syndrome are characterized by insulin resistance, obesity and a
predisposition to hypertension, dyslipidaemia, pancreatic β-cell dysfunction, type 2 diabetes …

ABSTRACT HARDIE, DG AMP-Activated Protein Kinase: A Key System Mediating Metabolic
Responses to Exercise. Med. Sci. Sports Exerc., Vol. 36, No. 1, pp. 28–34, 2004. The finding …

We recently demonstrated that the LKB1 tumour suppressor kinase, in complex with the
pseudokinase STRAD and the scaffolding protein MO25, phosphorylates and activates AMP …

CBS domains are defined as sequence motifs that occur in several different proteins in all
kingdoms of life. Although thought to be regulatory, their exact functions have been …

We investigated the importance of the two catalytic α-isoforms of the 5′-AMP-activated
protein kinase (AMPK) in 5-aminoimidazole-4-carboxamide-1-β-4-ribofuranoside (AICAR) …

Protein synthesis consumes a high proportion of the metabolic energy of mammalian cells,
and most of this is used by peptide chain elongation. An important regulator of energy …

A necessary mediator of cardiac myocyte enlargement is protein synthesis, which is
controlled at the levels of both translation initiation and elongation. Eukaryotic elongation …

AMP-activated protein kinase (AMPK) is tightly regulated by the cellular AMP: ATP ratio and
plays a central role in the regulation of energy homeostasis and metabolic stress. A …

Activation of AMP-activated protein kinase (AMPK) by exercise and metformin is beneficial
for the treatment of type 2 diabetes. We recently found that, in cultured cells, the LKB1 tumor …

Energy homeostasis and feeding are regulated by the central nervous system. C75, a fatty
acid synthase (FAS) inhibitor, causes weight loss and anorexia, implying a novel central …