In the past decade, there has been an explosion of interest in hyaluronan, an often
misunderstood, biochemically simple, yet functionally complex carbohydrate polymer that is …

Hyaluronan (HA) is an important constituent of the extracellular matrix and accumulates
during inflammatory lung diseases like asthma. Little is known about the factors that regulate …

Using “real-time RT-PCR”, we assessed the expression of three different hyaluronan
synthase genes, HAS1, HAS2, and HAS3, by measuring their mRNA amounts in cultured …

This study compares the regulation of three isoforms of hyaluronan synthase (HAS1, HAS2,
and HAS3) transcripts and hyaluronan (HA) production by cytokines in human synovial …

For circulating lymphocytes to migrate to inflammatory sites, they must first adhere to the
target tissue endothelium with sufficient strength to overcome the shear forces of blood flow …

Objective. Glucocorticoids are still a mainstay in the treatment of rheumatoid arthritis (RA).
Unfettered hyaluronan release is a hallmark of RA. The discovery of three genes encoding …

In acute rejection of transplanted organs intragraft fibroblasts increase their production of
hyaluronan. Hyaluronan has strong water binding capacity and an increased tissue content …

Muscular inactivity leads to atrophy and decreased fatigue resistance. The focus of this work
has been to use microarrays and bioinformatics approaches to better understand the …

3.1 Introduction...................................................................................................... 130 3.2
Aims................................................................................................................. 131 3.3 …