Growing evidence suggests that a major physiological function of the cannabinoid signaling
system is to modulate neuroinflammation. This review discusses the anti‐inflammatory …

The cannabinoid signaling system is composed of cannabinoid (CB) receptors, their
endogenous ligands, the endocannabinoids, and the enzymes that produce and inactivate …

The endocannabinoid system consists of two cannabinoid (CB) receptors, seven ligands,
and ligand-catabolizing enzymes such as fatty acid amid hydrolase (FAAH) and …

The antigen-induced release of histamine from sensitized guinea pig mast cells was dose-
dependently reduced by endogenous (2-arachidonylglycerol; 2AG) and exogenous [(1 R, 3 …

Offering details on the pharmacology of itch, techniques of itch evaluation, and neurogenic
itch, this reference presents new concepts in the neurophysiology and central mechanisms …

We have observed that treatment of human glioma cells with morphine in the nanomolar
range of concentration affects the mitochondrial membrane potential. The effect is specific to …

The history of the therapeutic use of Cannabis sativa L. in humans goes back approximately
3000 years, first mentioned by the Emperor Shen Nung in the Chinese Compendium of …

Pedal ganglia excised and maintained in culture for up to 2 h, release NO at low levels. The
range can vary between 0 to 1.1 nM. Non-stimulated immunocytes do not significantly …

Cannabinoids are well known for their effects on neurotransmission in the central nervous
system. Whereas the components of cannabinoid signaling have been intensively studied in …

Although∆ 9 (-)-tetrahydrocannabinol (THC) is not naturally found in the body, receptors for
this compound in the brain have been described since 1988 (Devane et al., 1988). These …