Protein physics is grounded on three fundamental experimental facts: protein, this long
heteropolymer, has a well defined compact three-dimensional structure; this structure can …

We present a new approach that combines electronic structure methods and molecular
dynamics simulations to investigate the infrared spectroscopy of condensed phase systems …

This mini-review describes how single-molecule sensitive fluorescence resonance energy
transfer (FRET) and photoinduced electron transfer (PET) reactions can be successfully …

The folded (alpha helical) and unfolded (non-alpha helical) ensembles of the 21 amino acid
peptide Ace-A21-Nme are characterized structurally. The replica exchange molecular …

We show that the five-helix bundle λ 6–85 can be engineered and solvent-tuned to make the
transition from activated two-state folding to downhill folding. The transition manifests itself …

It is well-known that end caps and the peptide length can dramatically influence the
thermodynamics of the helix− coil transition. However, their roles in determining the kinetics …

Two classes of λ6-85 mutants (those richer in alanine, and those richer in glycine) have very
similar slopes in an Arrhenius plot of the unfolding rates but very different temperature …

To further understand oligomeric protein assembly, the folding and unfolding kinetics of the
H3–H4 histone tetramer have been examined. The tetramer is the central protein component …

The intrachain fluorescence quenching of the fluorophore 2, 3-diazabicyclo [2.2. 2] oct-2-ene
(DBO) is measured in short peptide fragments, namely the two strands and the turn of the N …

Chain length and site dependencies of amide I local mode frequencies of α-helical
polyalanines are theoretically studied by carrying out semiempirical quantum chemistry …