The neural crest (NC) yields pluripotent cells endowed with migratory properties. They give
rise to neurons, glia, melanocytes and endocrine cells, and to diversemesenchymal' …

Proteins from the Polycomb group (PcG) are epigenetic chromatin modifiers involved in
cancer development and also in the maintenance of embryonic and adult stem cells. The …

Neural crest-derived cells that form the enteric nervous system undergo an extensive
migration from the caudal hindbrain to colonize the entire gastrointestinal tract. Mice in …

The receptor tyrosine kinases (RTKs) RET, MET, and RON all carry the Met p+ 1loop→ Thr
point mutation (ie, 2B mutation), leading to the formation of tumors with high metastatic …

Hirschsprung disease (HSCR) is a multigenic, congenital disorder that affects 1 in 5,000
newborns and is characterized by the absence of neural crest–derived enteric ganglia in the …

Hirschsprung disease occurs in approximately 1 in 5000 live born infants. This condition is a
developmental disorder of the enteric nervous system and is characterized by the absence …

The Ret receptor tyrosine kinase plays a crucial role in the development of the enteric
nervous system and the kidney. Tyrosine 1062 in Ret represents a binding site for the …

Cumulative evidence suggests that Hirschsprung disease (HSCR) is the consequence of
multiple gene interactions that modulate the ability of enteric neural crest (NC) cells to …

All peripheral autonomic neurons arise from neural crest cells that migrate away from the
neural tube and navigate to the location where ganglia will form. After differentiating into …

Latent precursors or stem cells of neural crest origin are present in a variety of post-
embryonic tissues. Although these cells are of biomedical interest for roles in human health …