Flagella contribute to the virulence of pathogenic bacteria through chemotaxis, adhesion to
and invasion of host surfaces. Flagellin is the structural protein that forms the major portion …

G-protein-coupled receptors (GPCR) are involved in directly and indirectly controlling an
extraordinary variety of physiological functions. Their key roles in cellular communication …

Skin is the most commonly affected organ in graft-versus-host disease (GVHD). To explore
the role of Langerhans cells in GVHD, the principal dendritic cells of the skin, we studied the …

Discrimination between beneficial commensal organisms and potentially harmful pathogens
is a central component of the essential role that gut immune cells play in maintaining the …

Chemokines are small chemoattractant cytokines that control a wide variety of biological and
pathological processes, ranging from immunosurveillance to inflammation, and from viral …

PURPOSE Macrophage inflammatory protein-3α (Mip-3α) is part of a family of chemotactic
cytokines involved in recruiting inflammatory cells throughout the body. CCR6 is a G-protein …

Background & Aims: The follicle-associated epithelium (FAE) that overlies Peyer's patches
(PPs) exhibits distinct features compared with the adjacent villus epithelium. Besides the …

The CC chemokine receptors CCR6, CCR9, and CCR10 all contribute to the positioning of
leukocytes at mucosal locations. Mucosal epithelial cells are major sources of the …

Ulcerative colitis (UC) and Crohn's disease (CD), collectively termed inflammatory bowel
diseases (IBD), represent chronic relapsing and remitting inflammatory disorders of the …

We have previously studied B cells, from people and mice, that express rotavirus-specific
surface immunoglobulin (RV-sIg) by flow cytometry with recombinant virus-like particles that …