[图书][B] Biomaterials for delivery and targeting of proteins and nucleic acids
RI Mahato - 2004 - taylorfrancis.com
Newcomers to the field of biopharmaceuticals require an understanding of the basic
principles and underlying methodology involved in developing protein-and nucleic acid …
principles and underlying methodology involved in developing protein-and nucleic acid …
Polyacetylenic compounds and butanol fraction from Bidens pilosa can modulate the differentiation of helper T cells and prevent autoimmune diabetes in non-obese …
SL Chang, CLT Chang, YM Chiang, RH Hsieh… - Planta …, 2004 - thieme-connect.com
Compelling evidence suggests that infiltrating CD4+ type I helper T (Th1) cells in the
pancreatic islets play a pivotal role in the progression of diabetes in non-obese diabetic …
pancreatic islets play a pivotal role in the progression of diabetes in non-obese diabetic …
Role of apoptosis in autoimmunity
Autoimmune diseases are characterized by the activity of autoreactive lymphocytes that
produce antibodies targeting self tissue or organ for destruction. Although the pathogenesis …
produce antibodies targeting self tissue or organ for destruction. Although the pathogenesis …
Vascular endothelial growth factor gene delivery for revascularization in transplanted human islets
AS Narang, K Cheng, J Henry, C Zhang, O Sabek… - Pharmaceutical …, 2004 - Springer
Purpose. Islet transplantation is limited by islet graft failure because of poor
revascularization, host immune rejection, and nonspecific inflammatory response. Human …
revascularization, host immune rejection, and nonspecific inflammatory response. Human …
[HTML][HTML] Prevention of type 1 diabetes by gene therapy
C Tian, J Bagley, N Cretin, N Seth… - The Journal of …, 2004 - Am Soc Clin Investig
The autoimmune disease type 1 diabetes in humans and NOD mice is determined by
multiple genetic factors, among the strongest of which is the inheritance of diabetes …
multiple genetic factors, among the strongest of which is the inheritance of diabetes …
Resiquimod is a modest adjuvant for HIV-1 gag-based genetic immunization in a mouse model
M Otero, SA Calarota, B Felber, D Laddy, G Pavlakis… - Vaccine, 2004 - Elsevier
DNA vaccines have been effective at generating useful immune responses in many animal
species. However, it is clearly desirable to increase their potency. The identification of …
species. However, it is clearly desirable to increase their potency. The identification of …
Adenovirus-based vascular endothelial growth factor gene delivery to human pancreatic islets
Islet transplantation is limited by islet graft failure due to poor revascularization, host immune
rejection and nonspecific inflammatory response. Delivery of human vascular endothelial …
rejection and nonspecific inflammatory response. Delivery of human vascular endothelial …
Regulatory T‐cells in type 1 diabetes
AE Juedes, MG von Herrath - Diabetes/metabolism research …, 2004 - Wiley Online Library
Type 1 diabetes is a T‐cell‐mediated autoimmune disease, resulting in destruction of the
insulin‐producing beta cells in the pancreas. Disease progression is thought to involve the …
insulin‐producing beta cells in the pancreas. Disease progression is thought to involve the …