Desmin is a muscle-specific protein and a key subunit of the intermediate filament in cardiac,
skeletal and smooth muscles. Desmin filaments are mainly located at the periphery of Z-disk …

Intermediate filaments provide scaffolding for the cell and protect it against stress. This
comprehensive review points out that there are more than 100 intermediate filament genes …

Intermediate filaments are cytoskeletal polymers encoded by a large family of differentially
expressed genes that provide crucial structural support in the cytoplasm and nucleus of …

Desmin, the major intermediate filament (IF) protein of muscle, is evolutionarily highly
conserved from shark to man. Recently, an increasing number of mutations of the desmin …

Desmin is the intermediate filament (IF) protein occurring exclusively in muscle and
endothelial cells. There are other IF proteins in muscle such as nestin, peripherin, and …

Mechanical interactions between desmin and Z-disks, costameres, and nuclei were
measured during passive deformation of single muscle cells. Image processing and …

One of the hallmarks of cardiomyopathy and heart failure is pronounced and progressive
cardiomyocyte death. Understanding the mechanisms involved in cardiomyocyte cell death …

The efficient functioning of striated muscle is dependent upon the structure of several
cytoskeletal networks including myofibrils, microtubules, and intermediate filaments …

Cardiac hypertrophy—that is, enlargement of the heart resulting from increased myocyte
size—is observed with many forms of human heart disease. It may arise secondary to an …

The cardiac myocyte has an intracellular scaffold, the cytoskeleton, which has been
implicated in several cardiac pathologies including hypertrophy and failure. In this review we …