Memory CD8 T cells are an important component of protective immunity against viral
infections, and understanding their development will aid in the design of optimal vaccines …

Hepatitis C virus (HCV) infects over 170 million people worldwide. Chronic infection occurs
in 50–80% of cases and eventually leads to cirrhosis and hepatocellular carcinoma. The …

Abstract The CD4+ CD25+ regulatory T lymphocytes have been implicated in suppressing T
cell immune responses. Our aim was to characterize the frequency, phenotype, function, and …

Hepatic immunobiology is paradoxical: although the liver possesses unusual tolerogenic
properties, it is also the site of effective immune responses against multiple pathogens and …

In the setting of acute hepatitis C virus (HCV) infection, robust HCV-specific CD8+ cytotoxic T
lymphocyte (CTL) responses are associated with initial control of viremia. Despite these …

Background & Aims: Recent evidence suggests that toll-like receptors (TLRs) recognize
certain viruses. We reported that hepatitis C virus (HCV) core and nonstructural 3 (NS3) …

The establishment of viral persistence generally requires evasion of the host CD8+ T cell
response. Here we describe a form of evasion wherein the CD8+ T cells are fully capable of …

Regulatory T (TR) cells consist of phenotypically and functionally distinct CD4+ and CD8+ T
cell subsets engaged both in maintaining self-tolerance and in preventing anti–non-self …

Background & Aims: Cellular immune responses are thought to play a key role in the
resolution of primary HCV infection. Although it has been consistently shown that CD4+ T …

The key feature of the adaptive immune response is its specificity and the ability to generate
and maintain memory. Preexisting antibodies in the circulation and at the mucosa provide …