Over the past decade, microbiology and infectious disease research have undergone the
most profound revolution since the times of Pasteur. Genomic sequencing has revealed the …

Almost all vaccinations today are delivered through parenteral routes. Mucosal vaccination
offers several benefits over parenteral routes of vaccination, including ease of …

The conventional approach to vaccine development is based on dissection of the pathogen
using biochemical, immunological and microbiological methods. Although successful in …

Since its introduction, vaccinology has been very effective in preventing infectious diseases.
However, in several cases, the conventional approach to identify protective antigens, based …

Mycobacterium bovis BCG vaccine significantly reduces the risk of tuberculosis by 50% and
continues to be used to prevent tuberculosis around the world. However, it has been shown …

Most of the existing vaccines share two general characteristics; with very few exceptions,
they are parenterally administered. In addition, they are formulated together with adjuvants …

Vaccination is an effective possibility to prevent many bacterial or viral infections, but for
several important pathogens still no vaccines are available. The sequences of complete …

Meningococcal meningitis and septicaemia are devastating diseases caused by the
infection of Neisseria meningitidis (meningococcus), a Gram-negative, capsulated …

The potential of genomics-based approaches to expand our understanding of the biology of
pathogens was summarized in an editorial by Dr. Barry Bloom, current Director of the …

Reverse vaccinology is a relatively new approach aimed at facilitating and accelerating the
discovery of vaccine candidates. It basically consists of the exploitation of genome …