Microbubbles in medical imaging: current applications and future directions

JR Lindner - Nature reviews Drug discovery, 2004 - nature.com
Not all bubbles in the bloodstream are detrimental. During the past decade, contrast-
enhanced ultrasound has evolved from a purely investigational tool to a routine diagnostic …

Ultrasonic drug delivery–a general review

WG Pitt, GA Husseini, BJ Staples - Expert opinion on drug delivery, 2004 - Taylor & Francis
Ultrasound has an ever-increasing role in the delivery of therapeutic agents, including
genetic material, protein and chemotherapeutic agents. Cavitating gas bodies, such as …

Therapeutic applications of lipid-coated microbubbles

EC Unger, T Porter, W Culp, R Labell… - Advanced drug delivery …, 2004 - Elsevier
Lipid-coated microbubbles represent a new class of agents with both diagnostic and
therapeutic applications. Microbubbles have low density. Stabilization of microbubbles by …

Microbubbles and ultrasound: from diagnosis to therapy

PA Dijkmans, LJM Juffermans… - European Journal of …, 2004 - academic.oup.com
The development of ultrasound contrast agents, containing encapsulated microbubbles, has
increased the possibilities for diagnostic imaging. Ultrasound contrast agents are currently …

In vivo molecular and genomic imaging: new challenges for imaging physics

SR Cherry - Physics in Medicine & Biology, 2004 - iopscience.iop.org
The emerging and rapidly growing field of molecular and genomic imaging is providing new
opportunities to directly visualize the biology of living organisms. By combining our growing …

Ultrasound-induced encapsulated microbubble phenomena

M Postema, A Van Wamel, CT Lancée… - Ultrasound in medicine & …, 2004 - Elsevier
When encapsulated microbubbles are subjected to high-amplitude ultrasound, the following
phenomena have been reported: oscillation, translation, coalescence, fragmentation, sonic …

The use of microbubbles to target drug delivery

JM Tsutsui, F Xie, RT Porter - Cardiovascular Ultrasound, 2004 - Springer
Ultrasound-mediated microbubbles destruction has been proposed as an innovative method
for noninvasive delivering of drugs and genes to different tissues. Microbubbles are used to …

The powerful microbubble: from bench to bedside, from intravascular indicator to therapeutic delivery system, and beyond

SB Feinstein - American Journal of physiology-heart and …, 2004 - journals.physiology.org
This review discusses the development, current applications, and therapeutic potential of
ultrasound contrast agents. Microbubbles containing gases act as true, intravascular …

Molecular imaging with contrast ultrasound and targeted microbubbles

JR Lindner - Journal of Nuclear Cardiology, 2004 - Springer
There is growing interest in the development of methods for imaging cellular and molecular
mediators of cardiovascular diseases. Techniques for imaging molecular and cellular …

Impact of myocardial contrast echocardiography on vascular permeability: comparison of three different contrast agents

P Li, WF Armstrong, DL Miller - Ultrasound in medicine & biology, 2004 - Elsevier
Microvascular permeabilization, petechial hemorrhage and premature ventricular
contractions (PVCs) have been demonstrated in an in vivo rat model of myocardial contrast …