An evaluation of the role of insulin-like growth factors (IGF) and of type-I IGF receptor signalling in hepatocarcinogenesis and in the resistance of hepatocarcinoma …
C Alexia, G Fallot, M Lasfer, G Schweizer-Groyer… - Biochemical …, 2004 - Elsevier
Strong evidence emphasizes the role of the insulin-like growth factor (IGF) system and of
type-I IGF receptor (IGF-IR) signalling in tumourigenesis. In this connection:(i) changes in the …
type-I IGF receptor (IGF-IR) signalling in tumourigenesis. In this connection:(i) changes in the …
The insulin-like growth factor-II/mannose-6-phosphate receptor: structure, distribution and function in the central nervous system
C Hawkes, S Kar - Brain Research Reviews, 2004 - Elsevier
The insulin-like growth factor-II/mannose-6-phosphate (IGF-II/M6P) receptor is a
multifunctional single transmembrane glycoprotein which, along with the cation-dependent …
multifunctional single transmembrane glycoprotein which, along with the cation-dependent …
[PDF][PDF] Role of estrogen receptor alpha in modulating IGF-I receptor signaling and function in breast cancer
E Surmacz, M Bartucci - Journal of Experimental and Clinical …, 2004 - researchgate.net
The insulin-like growth factor I (IGF-I) receptor (IGF-IR) is a multifunctional transmembrane
tyrosine kinase that has been implicated in neoplastic transformation. The tumorigenic …
tyrosine kinase that has been implicated in neoplastic transformation. The tumorigenic …
Imprinting of the human L3MBTL gene, a polycomb family member located in a region of chromosome 20 deleted in human myeloid malignancies
J Li, AJ Bench, GS Vassiliou… - Proceedings of the …, 2004 - National Acad Sciences
L3MBTL encodes a member of the Polycomb family of proteins, which, together with
Trithorax group proteins, is responsible for the coordinated regulation of patterns of gene …
Trithorax group proteins, is responsible for the coordinated regulation of patterns of gene …
The therapeutic potential of agents targeting the type I insulin-like growth factor receptor
H Zhang, D Yee - Expert opinion on investigational drugs, 2004 - Taylor & Francis
The type I insulin-like growth factor receptor (IGF-1R) is a receptor tyrosine kinase that
mediates insulin-like growth factor I (IGF-1) and IGF-2 signalling. Increased expression …
mediates insulin-like growth factor I (IGF-1) and IGF-2 signalling. Increased expression …
The role of the M6P/IGF-II receptor in cancer: tumor suppression or garbage disposal?
CD Scott, SM Firth - Hormone and metabolic research, 2004 - thieme-connect.com
Abstract The mannose 6-phosphate/insulin-like growth factor-II receptor (M6P/IGF-IIR) is an
intriguing protein with multiple ligands and multiple functions. Approximately 90-95% of the …
intriguing protein with multiple ligands and multiple functions. Approximately 90-95% of the …
Mono-and bivalent ligands bearing mannose 6-phosphate (M6P) surrogates: targeting the M6P/insulin-like growth factor II receptor
DB Berkowitz, G Maiti, BD Charette, CD Dreis… - Organic …, 2004 - ACS Publications
Mannose 6-phosphate mimics locked into the α-configuration and bearing hydrolase-
resistant phosphate surrogates were synthesized and evaluated for binding affinity to the …
resistant phosphate surrogates were synthesized and evaluated for binding affinity to the …
Down-regulation of the M6P/IGF-II receptor increases cell proliferation and reduces apoptosis in neonatal rat cardiac myocytes
Z Chen, Y Ge, JX Kang - BMC cell biology, 2004 - Springer
Background The mannose 6-phosphate/insulin-like growth factor-II receptor (M6P/IGF2R) is
a multi-functional protein that has been implicated in regulation of cell growth and apoptosis …
a multi-functional protein that has been implicated in regulation of cell growth and apoptosis …
Demonstration of tumor suppression by mannose 6-phosphate/insulin-like growth factor 2 receptor
J Li, GG Sahagian - Oncogene, 2004 - nature.com
Abstract The mannose 6-phosphate/IGF-2 receptor has been proposed to be a tumor
suppressor gene on the basis of loss of heterozygosity and mutations in tumors from cancer …
suppressor gene on the basis of loss of heterozygosity and mutations in tumors from cancer …
The use of cytogenetics in understanding ovarian cancer
M Bernardini, J Weberpals, JA Squire - Biomedicine & pharmacotherapy, 2004 - Elsevier
The future of cancer research is no longer limited to epidemiological data and clinical
management, but rather encompasses a new dimension of understanding, that involves …
management, but rather encompasses a new dimension of understanding, that involves …