A revival of bispecific antibodies
P Kufer, R Lutterbüse, PA Baeuerle - Trends in biotechnology, 2004 - cell.com
Bispecific antibodies usually do not occur in nature but are constructed by recombinant DNA
or cell-fusion technologies. Most are designed to recruit cytotoxic effector cells of the …
or cell-fusion technologies. Most are designed to recruit cytotoxic effector cells of the …
Antibodies and gene therapy: teaching old 'magic bullets' new tricks
L Sanz, B Blanco, L Alvarez-Vallina - TRENDS in Immunology, 2004 - cell.com
The emergence of recombinant technologies has revolutionized the selection and
production of monoclonal antibodies, allowing the design of fully human antibodies of any …
production of monoclonal antibodies, allowing the design of fully human antibodies of any …
Vaccine and antibody-directed T cell tumour immunotherapy
S Dermime, DE Gilham, DM Shaw, EJ Davidson… - … et Biophysica Acta (BBA …, 2004 - Elsevier
Clearer evidence for immune surveillance in malignancy and the identification of many new
tumour-associated antigens (TAAs) have driven novel vaccine and antibody-targeted …
tumour-associated antigens (TAAs) have driven novel vaccine and antibody-targeted …
Anti-CD3× Anti-HER2 bispecific antibody effectively redirects armed t cells to inhibit tumor development and growth in hormone-refractory prostate cancer–bearing …
PA Davol, JA Smith, N Kouttab, GJ Elfenbein… - Clinical prostate …, 2004 - Elsevier
The bispecific antibody (BiAb) anti-CD3× anti-Her2/neu (Her2Bi), combines Her2/neu
targeting with nonmajor histocompatibility complex–restricted cytotoxicity mediated by …
targeting with nonmajor histocompatibility complex–restricted cytotoxicity mediated by …
Cells expressing anti-Fc receptor binding components
T Keler, J Goldstein, R Graziano, YM Deo - US Patent 6,682,928, 2004 - Google Patents
Cells transformed to express on their surface a component which binds to an Fc receptor of
an effector cell are disclosed. Also disclosed are expression vectors used to transform the …
an effector cell are disclosed. Also disclosed are expression vectors used to transform the …
Progression of spontaneous autoimmune diabetes is associated with a switch in the killing mechanism used by autoreactive CTL
H Qin, JD Trudeau, GSD Reid, IF Lee… - International …, 2004 - academic.oup.com
Autoimmune (type 1) diabetes mellitus results from the destruction of insulin-producing
pancreatic β-cells by T lymphocytes. β-cell death that is induced by autoreactive CTL in …
pancreatic β-cells by T lymphocytes. β-cell death that is induced by autoreactive CTL in …
Measurement of intercellular conjugates by flow cytometry
DM Segal - Current protocols in immunology, 2004 - Wiley Online Library
Abstract Analysis of fluorescently labeled cellular aggregates can be accomplished quickly
and accurately with the technique of flow cytometry. With a dual‐laser flow cytometer, the …
and accurately with the technique of flow cytometry. With a dual‐laser flow cytometer, the …