Asthma and eczema (atopic dermatitis) are the most common chronic diseases of childhood.
These diseases are characterized by the production of high levels of immunoglobulin E in …

Psoriasis and atopic dermatitis are chronic and relapsing inflammatory diseases of the skin
associated with various immunologic abnormalities. Approximately 30% of psoriasis patients …

We have sequenced and annotated the genome of the filamentous ascomycete Ashbya
gossypii. With a size of only 9.2 megabases, encoding 4718 protein-coding genes, it is the …

Susceptibility to asthma depends on variation at an unknown number of genetic loci. To
identify susceptibility genes on chromosome 7p, we adopted a hierarchical genotyping …

Abstract Information from the human genome sequence will eventually alter many aspects of
clinical practice. It will increase through our understanding of disease mechanisms, and …

Background: Hypertrophic cardiomyopathy (HCM) is an autosomal dominant disease
caused by mutations in sarcomeric genes. However, extensive genetic screening failed to …

The prevalence of complex genetic immune disorders, such as asthma, arthritis and
diabetes, has escalated in recent decades. Despite the formidable challenges posed by the …

Background Previous genetic studies have associated the region of the human genome
(14q22. 1) containing the gene for the prostanoid DP receptor (PTGDR) with asthma. A study …

BACKGROUND: The role of variation in the IL4 gene in asthma and allergy susceptibility is
controversial. This cytokine is important in IgE isotype switching and the regulation of …

Dipeptidyl peptidase (DP) IV has a distinct substrate specificity in hydrolyzing a post-proline
bond. Here we present novel data on the sizes and tissue distribution of human and rat gene …