Diversity of inhibitory neurotransmission through GABAA receptors

I Mody, RA Pearce - Trends in neurosciences, 2004 - cell.com
In the brain, highly connected and heterogeneous GABAergic cells are crucial in controling
the activity of neuronal networks. They accomplish this task by communicating through …

Analysis of GABAA Receptor Function and Dissection of the Pharmacology of Benzodiazepines and General Anesthetics Through Mouse Genetics

U Rudolph, H Möhler - Annu. Rev. Pharmacol. Toxicol., 2004 - annualreviews.org
GABAA receptors are molecular substrates for the regulation of vigilance, anxiety, muscle
tension, epileptogenic activity, and memory functions, and the enhancement of GABAA …

Synaptic signaling between GABAergic interneurons and oligodendrocyte precursor cells in the hippocampus

S Lin, DE Bergles - Nature neuroscience, 2004 - nature.com
Oligodendrocyte precursor cells (OPCs) express receptors for many neurotransmitters, but
the mechanisms responsible for their activation are poorly understood. We have found that …

γ-Aminobutyric acid A receptor subunit mutant mice: new perspectives on alcohol actions

SL Boehm II, I Ponomarev, AW Jennings… - Biochemical …, 2004 - Elsevier
γ-Aminobutyric acid A (GABAA) receptors are believed to mediate a number of alcohol's
behavioral actions. Because the subunit composition of GABAA receptors determines …

Effects of status epilepticus on hippocampal GABAA receptors are age-dependent

G Zhang, YH Raol, FC Hsu, DA Coulter… - Neuroscience, 2004 - Elsevier
Long-term GABAA receptor alterations occur in hippocampal dentate granule neurons of
rats that develop epilepsy after status epilepticus in adulthood. Hippocampal GABAA …

Parvalbumin‐containing interneurons in the basolateral amygdala express high levels of the α1 subunit of the GABAA receptor

AJ McDonald, F Mascagni - Journal of Comparative Neurology, 2004 - Wiley Online Library
The basolateral amygdala (ABL) is essential for the amnestic effects of benzodiazepines in
aversive learning tasks. Because the α1 subunit of the γ‐aminobutyric acid (GABA) A …

Chronic unpredictable stress alters gene expression in rat single dentate granule cells

Y Qin, H Karst, M Joëls - Journal of neurochemistry, 2004 - Wiley Online Library
The rat adrenal hormone corticosterone binds to low and high affinity receptors, discretely
localized in brain, including the dentate gyrus. Differential activation of the two receptor …

Genetic manipulations of GABAA receptor in mice make inhibition exciting

S Vicini, P Ortinski - Pharmacology & therapeutics, 2004 - Elsevier
The inhibitory neurotransmitter γ-aminobutyric acid (GABA) plays an important role in brain
development and behavior. GABAA receptor subunits knock-out and knock-in mice have …

Quantitative effects produced by modifications of neuronal activity on the size of GABAA receptor clusters in hippocampal slice cultures

S Marty, R Wehrlé, JM Fritschy… - European Journal of …, 2004 - Wiley Online Library
The number and strength of GABAergic synapses needs to be precisely adjusted for
adequate control of excitatory activity. We investigated to what extent the size of GABAA …

The α1 and α6 subunit subtypes of the mammalian GABAA receptor confer distinct channel gating kinetics

JL Fisher - The Journal of physiology, 2004 - Wiley Online Library
The GABAA receptors show a large degree of structural heterogeneity, with seven different
subunit families, and 16 different subtypes in mammalian species. The α family is the largest …