Inhibitory MHC class I receptors were initially described on natural killer (NK) cells, where
they participate in inducing NK-cell self-tolerance. Inhibitory NK-cell receptors (iNKRs) can …

Natural killer (NK) cell function is negatively regulated by inhibitory receptors interacting with
major histocompatibility complex class I molecules expressed on target cells. Here we show …

To gain insight into NK cell dynamics, we investigated the turnover and proliferation rates of
NK cells in normal and lymphopenic conditions. In contrast to previous reports suggesting a …

Although it is known that activation of natural killer (NK) cells causes liver injury, the
mechanisms underlying NK cell‐induced killing of self‐hepatocytes are not clear. We …

Natural killer (NK) cells are the first line of defense against infection and transformation.
Additionally, NK cells can play seemingly opposite roles in autoimmune disease. Here, we …

A prediction from the" missing self" hypothesis is that down‐regulation of MHC class I on
resting hematopoietic cells should be sufficient to make them susceptible to NK cell killing …

The BALB/c inbred mouse strain is one of the most commonly used for immunological
studies and is an animal model for natural killer (NK) cell function during pathogen infection …

Ly-49 receptors are lectin-like type II transmembrane disulfide-bonded homodimers
expressed on natural killer (NK) cells and some T-cell subsets. Cell-mediated cytotoxicity …

Natural killer (NK) cells are an essential component of the innate immunity toward tumors
and virally infected cells. The function of NK cells is regulated by a precise balance between …

A novel murine NK cell-reactive mAb, AT8, was generated. AT8 recognizes Ly49G from
129/J, BALB/c, and related mouse strains, but does not bind to Ly49G B6. Costaining with …