Neuronal cell death is a key feature of both normal nervous system development and
neuropathological conditions. The Bcl-2 family, via its regulation of both caspase-dependent …

Neuronal death is a major factor in many neuropathologies, particularly traumatic, and yet
no neuroprotective therapies are currently available clinically, although antioxidants and …

Apoptotic cell death occurs in motoneurons in the neonate but not in the adult after a lesion
of a peripheral nerve. To investigate the molecular basis for this difference, we have …

Cell death/survival following traumatic brain injury (TBI) may be a result of alterations in the
intracellular ratio of death and survival factors. Bcl-2 family genes mediate both cell survival …

We examined the changes of two transcription factors, CREB and c‐Jun, in dorsal root
ganglia (DRG) after acute (8 or 48 hours) or chronic (10 days) cyclophosphamide (CYP) …

Midkine (MK), a heparin-binding growth factor, is produced in the developing and damaged
nervous system. However, the role of MK in peripheral nerve injury has not been clarified …

In this study we have taken advantage of the high nuclear responsiveness of type A sensory
ganglia neurons to variations of cellular activity to investigate the reorganization and …

This study shows the signaling pathway by which (2S, 3S, 4R)-N ″-cyano-N-(6-amino-3, 4-
dihydro-3-hydroxy-2-methyl-2-dimethoxymethyl-2H-benzopyran-4-yl)-N′-benzylguanidine …

Following sciatic nerve transection in adult rats, a proportion of injured dorsal root ganglion
(DRG) neurons die, through apoptosis, over the following 6 months. Axotomy also has …