Cancer is the second leading cause of death in the western world. Despite advances in
diagnosis and treatment, overall survival of patients remains poor. Scientific advances in …

Small cell lung cancer (SCLC) accounts for approximately 14% of all cases of lung cancer.
Combination chemotherapy is the most effective treatment modality for SCLC and recently …

The therapeutic efficacy of imatinib mesylate (Gleevec) is based on its specific inhibition of
the BCR-ABL oncogene protein, a widely expressed tyrosine kinase in chronic …

Background: Alternative treatment options are needed for advanced neuroblastoma patients
because their prognosis remains poor after intensive chemotherapy. Neuroblastoma cells …

Purpose: We identified the platelet-derived growth factor receptor α (PDGFRα) as an ovarian
cancer-specific gene by microarray hybridization using primary cultures. The purpose of this …

Feline vaccine-associated sarcoma (VAS) is a biologically aggressive soft-tissue sarcoma
that can develop at sites where inactivated feline vaccines have been administered. We …

The B-Raf V599E-mediated constitutive activation of ERK1/2 is involved in establishing the
transformed phenotype of some uveal melanoma cells (Calipel, A., Lefevre, G., Pouponnot …

The Kit receptor tyrosine kinase is a transmembrane receptor that is expressed in a variety of
different tissues and mediates pleiotropic biological effects through its ligand stem cell factor …

Abstract Purpose and Experimental Design: The stem cell factor/KIT receptor loop may
represent a novel target for molecular-based therapies of Ewing tumor. We analyzed the in …

Background: KIT is a transmembrane tyrosine kinase receptor, expressed in high amounts in
various normal cells. In addition, c-kit mutation or activation is a major pathogenetic event in …