DNA methylation is an important regulator of gene transcription, and its role in
carcinogenesis has been a topic of considerable interest in the last few years. Alterations in …

Chromatin immunoprecipitation (ChIP) is a well-established procedure used to investigate
interactions between proteins and DNA. Coupled with whole-genome DNA microarrays …

The laboratory rat (Rattus norvegicus) is an indispensable tool in experimental medicine
and drug development, having made inestimable contributions to human health. We report …

Epigenetic mechanisms act to change the accessibility of chromatin to transcriptional
regulation locally and globally via modifications of the DNA and by modification or …

Motivation: Recently, more stringent criteria for CpG islands have been introduced to
exclude Alu repeats, thereby enabling a higher proportion of CpG islands associating with …

The Human Epigenome Project aims to identify, catalogue, and interpret genome-wide DNA
methylation phenomena. Occurring naturally on cytosine bases at cytosine–guanine …

▪ Abstract The genomes from three mammals (human, mouse, and rat), two worms, and
several yeasts have been sequenced, and more genomes will be completed in the near …

During herpes simplex virus type 1 (HSV-1) latency, gene expression is tightly repressed
except for the latency-associated transcript (LAT). The mechanistic basis for this repression …

Approximately half of all human genes have CpG islands (CGIs) around their promoter
regions. Although CGIs usually escape methylation, those on Chromosome X in females …

A large familyof neural protocadherin (Pcdh) proteins is encoded bythree closelylinked
mammalian gene clusters (α, β, and γ). Pcdh α and γ clusters have a striking genomic …