The inhibitor of apoptosis proteins (IAPs) are a family of antiapoptotic proteins that bind and
inhibit caspases 3, 7, and/or 9, but not caspase 8. Growing evidence also indicates that IAPs …

The X-linked inhibitor of apoptosis protein (XIAP) is a potent cellular inhibitor of apoptosis.
Designing small-molecule inhibitors that target the BIR3 domain of XIAP, where …

The X-linked inhibitor of apoptosis (XIAP) is a promising new molecular target for the design
of novel anticancer drugs aiming at overcoming apoptosis-resistance of cancer cells to …

Inhibitor of apoptosis (IAP) proteins are overexpressed in many cancers and have been
implicated in tumor growth, pathogenesis, and resistance to chemo-or radiotherapy. On the …

A successful structure-based design of conformationally constrained second mitochondria-
derived activator of caspase (Smac) mimetics that target the XIAP/caspase-9 interaction site …

A mature form of nuclear-encoded mitochondrial serine protease HtrA2/Omi is pivotal in
regulating apoptotic cell death; however, the underlying mechanism of the processing event …

We have used a highly environment-sensitive fluorescent probe 6-bromoacetyl-2-
dimethylaminonaphthalene (badan) to study the interaction between calmodulin (CaM) and …

The inhibitor of apoptosis (IAP) genes have emerged as probably the most important
intrinsic regulators of apoptosis. The members of the IAP family are highly conserved in …

WO2004005248A1 - Peptide inhibitors of smac protein binding to inhibitor of apoptosis
proteins (iap) - Google Patents WO2004005248A1 - Peptide inhibitors of smac protein …