Despite the consistent amount of information accumulated in recent years on multiple
sclerosis (MS) in childhood, many clinicians still view this condition as an exclusively young …

The relationship of primary progressive multiple sclerosis (PPMS) to relapsing-remitting MS
(RRMS) and secondary progressive MS (SPMS) remains unclear. Natural history data from …

The association with HLA–DRB1 alleles was tested in 609 Continental Italian MS patients
and 836 controls. The phenotype frequency of DRB1* 15 in the patients was significantly …

The onset of multiple sclerosis (MS) in childhood is being increasingly recognized. Despite
this, there currently exist several barriers to the prompt diagnosis of MS in children. Many …

Background: The human leukocyte antigen (HLA) class II DR2 haplotype (DRB1* 1501,
DQA1* 0102, DQB1* 0602) has been associated with multiple sclerosis (MS) in all ethnic …

In a recent analysis of genotypes associated with multiple sclerosis (MS [MIM 126200]) in a
large data set of American families, Barcellos et al.(2003) demonstrated a dose effect of the …

Multiple sclerosis (MS) is an immune‐mediated demyelinating disease of the CNS that is
associated with HLA class II molecules HLA‐DR2,‐DR3 and‐DR4. Previously, it has been …

Human CD4+ T-cell epitopes were identified in interferon-beta (IFN-β)-1b. A prominent
peptide epitope region was found that induced a proliferative response in 16% of all donors …

Background: Investigation of coaffected sib pairs is one method to determine the genetic
influence on the clinical presentatio n of many complex diseases, such as multiple sclerosis …

TNF-related apoptosis-inducing ligand (TRAIL) is not only involved in cell death but also in
other immunoregulatory mechanisms. So far, the regulation of the TRAIL pathway in …