Background: Alzheimer's disease (AD), a progressive degenerative disorder of the brain, is
the most common cause of cognitive impairment in the elderly. The pharmacotherapy of AD …

Insufficient cholinergic neurotransmission in AD is responsible for a progressive loss of
cognition and motor capacities. The cholinergic hypothesis has provided the rationale for the …

Alzheimer's disease (AD) is characterized by progressive dementia caused by the loss of the
presynaptic markers of the cholinergic system in the brain areas related to memory and …

Among the neuropathological features of Alzheimer's disease (AD), are senile plaques and
dysfunction of cholinergic neurotransmission are the major hallmarks. Senile plaques are …

Objectives: Epidemiologic reports indicate that lipid-lowering agents (LLAs) protect against
dementia. We hypothesized that LLAs might affect cholinergic systems. The effects of LLAs …

Despite considerable progress in defining the role of the β-amyloid protein (Aβ) in the
pathogenesis of Alzheimer's disease (AD), the mechanism by which accumulation of Aβ …

Studies on neural networks indicate that the pattern of amnesia that occurs in Alzheimer's
disease (AD) can be reproduced by synaptic loss, but only when this loss is accompanied by …

Alzheimer's disease (AD) is a debilitating neurodegenerative disease and is the most
common cause of dementia in the elderly. A pathological hallmark of AD is the amyloid …