Nitric oxide (NO) is a pleiotrophic regulator, pivotal to numerous biological processes,
including vasodilation, neurotransmission, and macrophage-mediated immunity. The highly …

Nitric oxide (NO) is a potent intercellular signal in mammals that mediates key aspects of
blood pressure, hormone release, nerve transmission and the immune response of higher …

The role of nitric oxide and reactive oxygen species is well-demonstrated in inflammation. In
this study, we evaluated the effect of aminoguanidine, a nitric oxide synthase inhibitor, in a …

Three nitric oxide synthase (NOS) isoforms, eNOS, nNOS and iNOS, generate nitric oxide
(NO) crucial to the cardiovascular, nervous and host defense systems, respectively …

In vitro and in vivo studies have demonstrated that methylguanidine, an inhibitor of nitric
oxide synthase (NOS), is also able to reduce tumour necrosis factor-α (TNF-α) release. In the …

The overproduction of nitric oxide (NO) by inducible nitric oxide synthase (iNOS) may
contribute to the pathophysiology of intestinal injury induced by ischemia–reperfusion. The …

The aim of this study was to investigate the effect of GW274150, a novel, potent and
selective inhibitor of inducible nitric oxide synthase (iNOS) activity in a model of lung injury …

CHFSOFHQIZKQCR-UHFFFAOYSA-N O= C1NC2= C (NC1= O) C ([N+](= O)[O-])= C (Cl) C
(Cl)= C2 Chemical compound O= C1NC2= C (NC1= O) C ([N+](= O)[O-])= C (Cl) C (Cl)= C2 …

Septic shock, a severe form of sepsis, is characterized by cardiovascular collapse following
microbial invasion of the body. The progressive hypotension, hyporeactivity to vasopressor …

In a continuing effort to unravel the structural basis for isoform-selective inhibition of nitric
oxide synthase (NOS) by various inhibitors, we have determined the crystal structures of the …