Paradoxes of adherence and drug resistance to HIV antiretroviral therapy
DR Bangsberg, AR Moss… - Journal of antimicrobial …, 2004 - academic.oup.com
Public health debates about providing HIV antiretroviral therapy to impoverished
populations have centred on the relationship between adherence and risk of drug …
populations have centred on the relationship between adherence and risk of drug …
The impact of adherence on CD4 cell count responses among HIV-infected patients
E Wood, RS Hogg, B Yip, PR Harrigan… - JAIDS Journal of …, 2004 - journals.lww.com
Background There have been concerns that irreversible immune damage may result if
highly active antiretroviral therapy (HAART) is initiated after the CD4 cell count declines to …
highly active antiretroviral therapy (HAART) is initiated after the CD4 cell count declines to …
Modeling the HIV protease inhibitor adherence-resistance curve by use of empirically derived estimates
DR Bangsberg, TC Porco, C Kagay… - The Journal of …, 2004 - academic.oup.com
The standard view postulates a bell-shaped relationship between adherence to therapy and
development of drug-resistant human immunodeficiency virus (HIV), with a resistance peak …
development of drug-resistant human immunodeficiency virus (HIV), with a resistance peak …
Resistance to HIV protease inhibitors: mechanisms and clinical consequences
HIV-1 protease is an aspartic protease composed by two identical monomers, 99 amino
acids in length. Drug resistance is mainly mediated by structural changes in the substrate …
acids in length. Drug resistance is mainly mediated by structural changes in the substrate …
Resistance profiles and adherence at primary virological failure in three different highly active antiretroviral therapy regimens: analysis of failure rates in a randomized …
BT Røge, TS Barfod, O Kirk, TL Katzenstein… - HIV …, 2004 - Wiley Online Library
Objectives To investigate the interplay between resistance and adherence in the virological
failure of three fundamentally different highly active antiretroviral therapy (HAART) regimens …
failure of three fundamentally different highly active antiretroviral therapy (HAART) regimens …
Modeling the impact of modified directly observed antiretroviral therapy on HIV suppression and resistance, disease progression, and death
CR Kagay, TC Porco, CA Liechty… - Clinical infectious …, 2004 - academic.oup.com
A simulation model that used Markov assumptions with Monte Carlo uncertainty analysis
was evaluated 1500 times at 10,000 iterations. Modified directly observed therapy (MDOT) …
was evaluated 1500 times at 10,000 iterations. Modified directly observed therapy (MDOT) …
Virologic and immunologic response to highly active antiretroviral therapy
LP Jacobson, JP Phair, TE Yamashita - Current HIV/AIDS Reports, 2004 - Springer
Highly active antiretroviral therapy (HAART) delays clinical progression by suppressing viral
replication, measured by a substantial reduction in HIV RNA, allowing the immune system to …
replication, measured by a substantial reduction in HIV RNA, allowing the immune system to …
Update on the virologic and immunologic response to highly active antiretroviral therapy
LP Jacobson, JP Phair, TE Yamashita - Current Infectious Disease Reports, 2004 - Springer
Highly active antiretroviral therapy (HAART) delays clinical progression by suppressing viral
replication, measured by a substantial reduction in HIV RNA, allowing the immune system to …
replication, measured by a substantial reduction in HIV RNA, allowing the immune system to …
There are no paradoxes of adherence and drug resistance to HIV antiretroviral therapy
DA Green - Journal of Antimicrobial Chemotherapy, 2004 - academic.oup.com
1Epidemiology and Prevention Interventions Center, San Francisco General Hospital,
UCSF; 2San Francisco General Hospital AIDS Program, UCSF; 3Department of …
UCSF; 2San Francisco General Hospital AIDS Program, UCSF; 3Department of …
Mutations associated with hypersusceptibility... and with good adherence
TS Barfod - The Journal of infectious diseases, 2004 - academic.oup.com
To the Editor—In their excellent article, Tozzi et al. have shown that several nucleoside
reverse-transcriptase inhibitor (NRTI) mutations are associated with an increased probability …
reverse-transcriptase inhibitor (NRTI) mutations are associated with an increased probability …