The blood-brain barrier (BBB) efficiently restricts penetration of therapeutic agents to the
brain from the periphery. Therefore, discovery of new modalities allowing for effective …

The endothelial cells (EC) of the microvasculature in the brain form the anatomical basis of
the blood–brain barrier (BBB). In the present study, the effects of agents that modify the …

The communication of calcium signals between cells is known to be operative between
neurons where these signals integrate intimately with electrical and chemical signal …

purpose. To test the hypothesis that dynamic contrast-enhanced magnetic resonance
imaging (DCE-MRI) provides a useful in vivo measure of passive blood retinal barrier …

The effect of transient hypertension on blood-brain barrier (BBB) permeability, particularly on
extravasation of immunoglobulin G (IgG), has not been fully understood. In the present …

It is being increasingly suggested that the microcirculation, which is known to be in a large
part responsible for maintaining an adequate and constant microenvironment for function of …

The brain is composed of neurons that communicate electrical signals over neurites and
chemical signals across synapses, and non-neuronal cells like glial and vascular cells that …

The present study sought to determine whether an acute increase in arterial blood pressure
(ABP) reduces plasma vasopressin (VP) levels stimulated by ANG II or hyperosmolality …

Abstract Cerebral ischaemia ('stroke') is an acute neurodegenerative disease that is one of
the leading causes of death and disability in developed countries. As such it has enormous …

Reverse genetics has been greatly advanced by the discovery of RNA interference (RNAi).
This intracellular RNA-mediated gene silencing pathway is partially conserved from plants to …