Neo-clerodane diterpenoid, a new metalloprotease snake venom inhibitor from Baccharis trimera (Asteraceae): anti-proteolytic and anti-hemorrhagic properties

AH Januário, SL Santos, S Marcussi, MV Mazzi… - Chemico-biological …, 2004 - Elsevier
Many plants are used in traditional medicine as active agents against various effects
induced by snakebite. Few attempts have been made however to identify the nature of plant …

Bactericidal and neurotoxic activities of two myotoxic phospholipases A2 from Bothrops neuwiedi pauloensis snake venom

VM Rodrigues, S Marcussi, RS Cambraia… - Toxicon, 2004 - Elsevier
Two basic myotoxic PLA2s, namely BnpTX-I and II, were isolated from Bothrops neuwiedi
pauloensis snake venom through three chromatographic steps: ion-exchange …

A new hemorrhagic metalloprotease from Bothrops jararacussu snake venom: isolation and biochemical characterization

MV Mazzi, S Marcussi, GB Carlos, RG Stábeli… - Toxicon, 2004 - Elsevier
A hemorrhagic metalloprotease, named BjussuMP-I, was isolated from Bothrops jararacussu
snake venom by a combination of gel filtration on Sephacryl S-200 (0.01 M Tris–HCl, pH 7.6 …

Effect of crotapotin on the biological activity of Asp49 and Lys49 phospholipases A2 from Bothrops snake venoms

AL Cecchini, AM Soares, R Cecchini… - … and Physiology Part C …, 2004 - Elsevier
Myonecrosis, in addition to edema and other biological manifestations, are conspicuous
effects of Bothrops snake venoms, some of them caused by phospholipases A2 (PLA2s) …

A novel high molecular weight metalloproteinase cleaves fragment F1 of activated human prothrombin

RQ Chen, Y Jin, JB Wu, XD Zhou, D Li, QM Lu… - Toxicon, 2004 - Elsevier
A hemorrhagic proteinase, jerdohagin, was purified from Trimeresurus jerdonii venom by gel
filtration and ion-exchange chromatographies. It was a single chain polypeptide with an …