Nicotinic acetylcholine receptors (nAChRs) have been implicated in a number of
neurological disorders. 5-Iodo-3-[2 (S)-2-azetidinylmethoxy] pyridine (5-IA-85380) is a novel …

It is currently unclear whether impairment of the cholinergic system is present in Alzheimer
disease (AD) already at an early stage and to what extent it depends on degeneration of the …

The β‐amyloid protein (Aβ) is the major protein component of amyloid plaques found in the
Alzheimer brain. Although there is a loss of acetylcholinesterase (AChE) from both …

Alpha 7 nicotinic acetylcholine receptors are involved in learning and memory, and are
implicated in the pathology of Alzheimer's disease and schizophrenia. Detection of α7 …

Alzheimer's disease (AD) and dementia with Lewy bodies (DLB) are common forms of
dementia in the elderly. The neuropathology of AD and DLB is related to cholinergic …

Consistent deficits in the cholinergic system are evident in Alzheimer's disease (AD)
patients, including selective loss of α4β2 nicotinic acetylcholine receptors in the brains of AD …

The proteolytic fragment of collagen XVIII, endostatin, acts as an inhibitor of angiogenesis.
To date, only limited knowledge exists on the effects of endostatin on endothelial cells …

Nicotinic acetylcholine receptors (nAChRs) are implicated in a variety of disorders of the
human central nervous system including addiction to nicotine, Alzheimer's disease, anxiety …

The use of in vitro systems (cell culture, organotypic culture) is steadily increasing in all
areas of modern biomedical research. Cell biology, cancer research, and neuroscience are …

Neuroreceptor single photon emission computed tomography (SPECT) imaging provides a
powerful tool for the evaluation of the function of a neurotransmitter system in normal and or …