Human Toll-like receptors (TLRs) are crucial for the recognition of invading pathogens and
for the activation of both innate and adaptive immunity. Upon stimulation, TLRs recruit …

Human B cells that coexpress surrogate and conventional light chains (V-preB+ L+) show an
unusual heavy and light chain antibody repertoire that display evidence of receptor editing …

Systemic autoimmune diseases, such as systemic lupus erythematosus (SLE), are
associated with the production of a highly diverse autoantibody repertoire. Nevertheless, in …

Synthetic single-stranded oligodeoxynucleotides (15—30 bp) containing CpG motifs and
phosphorothioate backbones (CpG s-ODN), immune complexes consisting of anti …

We generated transgenic mice, designated SMI, expressing unmutated H and L chain Ig
genes encoding a low-affinity, polyreactive human (h) IgM/κ rheumatoid factor. These …

Autoreactive B cells are not completely purged from the primary B cell repertoire, and
whether they can be prevented from maturation into memory B cells has been uncertain. We …

To prevent the formation of autoantibody mediated autoimmune diseases, autoreactive B
cells are subjected to negative selection during the formation of the pre-immune repertoire …

We generated transgenic mice, designated SMI, expressing unmutated H and L chain Ig
genes encoding a low-affinity, polyreactive human (h) IgM/rheumatoid factor. These animals …

Autoreactive B cells are not completely purged from the primary B cell repertoire, and
whether they can be prevented from maturation into memory B cells has been uncertain. We …

H2 s mice develop an autoimmune disorder upon exposure to mercuric chloride (HgCl 2).
This disorder is biphasic, with rapid production of IgG autoantibodies specific for nucleolar …