Viruses are among the most common causes of opportunistic infection after transplantation
and the most important. The risk for viral infection is a function of the specific virus …

T-cell depletion facilitates reduced immunosuppression following organ transplantation and
has been suggested to be pro-tolerant. However, the characteristics of post-depletional T …

Lung transplantation is the only definitive therapy for many forms of end-stage lung
diseases. However, the success of lung transplantation is limited by many factors:(1) Too …

Renal allograft acute cellular rejection (ACR) is a T-cell mediated disease that is diagnosed
histologically. However, many normally functioning allografts have T-cell infiltrates and …

Abstract Both CD4+ and CD8+ human memory but not naive T cells respond to allogeneic
human dermal microvascular endothelial cells (HDMEC) in vitro by secreting cytokines and …

Background—The early inflammatory response during reperfusion of cardiac allografts is
initiated by the infiltration of polymorphonuclear leukocytes (PMNs) into the graft. The impact …

CD154-specific antibody therapy prevents allograft rejection in many experimental
transplant models. However, initial clinical transplant trials with anti-CD154 have been …

T-cell tolerance is mandatory for major histocompatibility complex (MHC)-mismatched stem-
cell transplantation without cytoreduction. Here, we used a cytotoxicity assay based on the …

In all but a small minority of cases, continued survival of solid organ grafts after
transplantation depends on lifelong, nonselective immunosuppression that, although …

The maintenance of T cell numbers in the periphery is mediated by distinct homeostatic
mechanisms that ensure the proper representation of naïve and memory T cells …