Akt kinases control essential cellular functions, including proliferation, apoptosis,
metabolism and transcription, and have been proposed as promising targets for treatment of …

The expression of the αvβ3 integrin (CD51/CD61) on human melanoma cells has been
shown to be associated most closely with tumor progression and metastases formation in …

This dissertation presents the development of textured scaffolds to provide osteoconductive
stimuli to CTPs (Connective Tissue Progenitor Cells) for bone regeneration applications …

Metastatic breast cancer cells have an increased propensity to metastasize to bone.
Whether bone has a unique chemotactic potential that attracts breast cancer cells is …

Metastasis to bone is a major complication of advanced cancer and occurs in more than
400,000 cancer patients each year. Bone metastasis can arise from many different tumor …

When tumors progress to greater malignancy, cells within the tumor develop an increasing
ability to detach from neighboring cells and invade through surrounding tissues and tissue …

Many adhesion-promoting components of the extracellular matrix contain closely spaced
proteoglycan-and integrin-binding domains, suggestive that these two classes of receptors …