Mounting evidence highlights the role of adipose tissue in the development of a systemic
inflammatory state that contributes to obesity-associated vasculopathy and cardiovascular …

Osteoporosis and atherosclerosis are both widely prevalent in an ageing population, and
induce serious morbidities and death. There is growing evidence that in addition to their …

Obesity is associated with marked increases in plasma leptin concentration, and
hyperleptinemia is an independent risk factor for coronary artery disease. As a result, the …

Objective: The term metabolic syndrome (MS) describes a cluster of cardiovascular risk
factors including dyslipidemia, glucose intolerance, insulin resistance, and hypertension …

Atherosclerotic CVD is the most common cause of death in the West. Yet, its pathogenesis
and early development are only partially understood. Central to the early atherosclerotic …

Insulin resistance is frequently accompanied by obesity and both obesity and type 2
diabetes are associated with a mild chronic inflammation. Elevated levels of various …

The hypertrophy of vascular smooth muscle cells (VSMCs) is critical in vascular remodeling
associated with hypertension, atherosclerosis, and restenosis. Recently, leptin has …

Retinoic acid (RA) administration and chronic vitamin A supplementation were reported to
inhibit adipose tissue leptin expression in rodents, but the impact of this effect on food intake …

Impaired leptin signalling in obesity is increasingly implicated in cardiovascular
pathophysiology. To explore mechanisms for leptin activity in the heart, we hypothesized …

BACKGROUND: Leptin may play an important role in the development of atherosclerosis.
We evaluated the effect of atorvastatin on leptin secretion in vivo and in vitro. METHODS …