DNA methylation is the epigenetic modification, which introduces 5mC as fifth base onto
DNA. As for the distribution of 5mCs, it is well known that they distribute themselves in a non …

During their development from progenitors, lymphocytes make a series of cell fate decisions.
These decisions reflect and require changes in overall programs of gene expression. To …

We provided evidence that competitive inhibition of poly (ADP-ribose) polymerases in
mammalian cells treated with 3-aminobenzamide causes DNA hypermethylation in the …

A large fraction of genes in the mammalian genome is repressed in every cell throughout
development. Here, we propose that this long-term silencing is carried out by distinct …

Over three decades ago DNA methylation had been suggested to play a role in the
regulation of gene expression. This chapter reviews the development of this field of research …

Abstract Mutations in APC, CTNNB1, AXIN1 or AXIN2 cause impairment in the β-catenin
degradation pathway and result in accumulation of β-catenin in a wide range of human …

Proper establishment and faithful maintenance of epigenetic information is crucial for the
correct development of complex organisms. For mammals, it is now accepted that DNA …

Recent mapping of nucleosome positioning on several long gene regions subject to DNA
methylation has identified instances of nucleosome repositioning by this base modification …

Hodgkin and Reed–Sternberg (HRS) cells of classical Hodgkin lymphoma (cHL) and
primary effusion lymphoma (PEL) are derived from germinal center (GC) and post-GC B …

While early transposon (ETn) endogenous retrovirus (ERV)-like elements are known to be
active insertional mutagens in the mouse, little is known about their transcriptional …