Iatrogenic hypoglycemia is a problem for people with diabetes. It causes recurrent morbidity,
and sometimes death, as well as a vicious cycle of recurrent hypoglycemia, precluding …

Insulin and its signaling systems are implicated in both central and peripheral mechanisms
governing the ingestion, distribution, metabolism, and storage of nutrients in organisms …

Glucose directly alters the action potential frequency of glucosensing neurons in the
ventromedial hypothalamic nucleus (VMN). Glucose-excited neurons increase, and glucose …

The mechanism (s) by which glucosensing neurons detect fluctuations in glucose remains
largely unknown. In the pancreatic β-cell, ATP-sensitive K+ channels (KATP channels) play …

In the present study, our aim was to determine whether intrafetal glucose infusion increases
fetal adiposity, synthesis and secretion of leptin and regulates gene expression of the …

Since nutrition-sensitive feedback signals normally act to maintain relatively stable levels of
both available and stored nutritional resources, failure in one or more of these feedback …

Neuropeptide Y (NPY) conjugated to saporin (NPY-SAP), a ribosomal inactivating toxin, is a
newly developed compound designed to selectively target and lesion NPY receptor …

Hypoglycemia is the most common acute complication associated with the treatment of type
1 diabetes. At the very least, it can be an unpleasant experience for many children, because …

The robust neuroendocrine counterregulatory responses induced by hypoglycemia protect
the brain by restoring plasma glucose, but little is known about molecular responses to …

This chapter provides an overview of the physiological mechanisms integrating metabolism
and reproduction. The reproductive system of some mammals is more sensitive than others …