▪ Abstract Natural killer T (NKT) cells constitute a conserved T cell sublineage with unique
properties, including reactivity for a synthetic glycolipid presented by CD1d, expression of an …

The review addresses the functional and structural properties of the two series of chalcogen
analogues of amino acids in peptides and proteins, the methionine and the serine/cysteine …

The glycolipid α-galactosylceramide binds with high affinity to CD1d and stimulates natural
killer T cells. Here we report the crystal structure of human CD1d in complex with synthetic α …

Natural killer T (NKT) cells are CD1d‐restricted lymphoid cells and are characterized by an
invariant T‐cell receptor, which in humans consists of a Vα24 chain paired with a Vβ11 …

CD1 proteins bind lipids to form antigen complexes that contact T-cell receptors and activate
T cells. Recent crystal structures of CD1 proteins show that their antigen-binding grooves …

Background Sarcoidosis is a multisystem disorder that predominantly involves the lungs,
characterised by a T-helper 1 (Th1) biased CD4-positive T-cell response and granuloma …

CD1d-restricted natural killer T (NKT) cells are involved in the regulation of various immune
responses, and have been shown to inhibit viral replication in animal hepatitis models when …

Invariant natural killer T (iNKT) cells are an unusual group of T lymphocytes that recognize
glycolipid antigens presented by the major histocompatibility complex class I-related protein …

The discovery of the CD1 antigen-presenting system reveals that T cells survey the lipid
content of target cells via T-cell receptor (TCR) contact with CD1 bound to lipids, glycolipids …

Understanding the protective mechanism in the liver induced by recombinant vaccines
against the pre-erythrocytic stages of malaria is important for vaccine development. Most …