Genetics of hereditary colorectal cancer

WS Jo, DC Chung - Seminars in oncology, 2005 - Elsevier
Genetic factors can dramatically influence the risk of colorectal cancer, and the molecular
bases of many hereditary colorectal cancer syndromes, including familial adenomatous …

Microsatellite instability of selective target genes in HNPCC-associated colon adenomas

SM Woerner, M Kloor, A Mueller, J Rueschoff… - Oncogene, 2005 - nature.com
Microsatellite instability (MSI) occurs in most hereditary nonpolyposis colorectal cancers
(HNPCC) and less frequently in sporadic tumors as the result of DNA mismatch repair …

Molecular phenotype of inflammatory bowel disease-associated neoplasms with microsatellite instability

K Schulmann, Y Mori, V Croog, J Yin, A Olaru… - Gastroenterology, 2005 - Elsevier
Background&Aims: Patients with inflammatory bowel disease (IBD) are at increased risk of
developing colorectal cancer (CRC). We sought to determine the frequency of high-level …

[HTML][HTML] The role of MLH1, MSH2 and MSH6 in the development of multiple colorectal cancers

DA Lawes, T Pearson, S Sengupta… - British journal of cancer, 2005 - nature.com
There is increased incidence of microsatellite instability (MSI) in patients who develop
multiple primary colorectal cancers (CRC), although the association with hereditary …

Microsatellite instability in gastrointestinal tract cancers: a brief update

S Oda, Y Zhao, Y Maehara - Surgery today, 2005 - Springer
Microsatellite instability (MSI) was initially reported in colorectal cancer and, particularly, in
hereditary nonpolyposis colorectal cancer (HNPCC). Since mutations in the genes …

Low level microsatellite instability may be associated with reduced cancer specific survival in sporadic stage C colorectal carcinoma

CM Wright, OF Dent, RC Newland, M Barker… - Gut, 2005 - gut.bmj.com
Background: Colorectal cancers (CRCs) may be categorised according to the degree of
microsatellite instability (MSI) exhibited, as MSI-high (MSI-H), MSI-low (MSI-L), or …

[图书][B] Silicon quantum integrated circuits: Silicon-germanium heterostructure devices: Basics and realisations

E Kasper, DJ Paul - 2005 - books.google.com
Quantum size effects are becoming increasingly important in microelectronics, as the
dimensions of the structures shrink laterally towards 100 nm and vertically towards 10 nm …

Microsatellite instability caused by hMLH1 promoter methylation increases with tumor progression in right-sided sporadic colorectal cancer

H Noda, Y Kato, H Yoshikawa, M Arai, K Togashi… - Oncology, 2005 - karger.com
Objective: A subset of sporadic colorectal cancers (SCRCs) exhibits microsatellite instability
(MSI). Most MSI in SCRCs is caused by hMLH1 inactivation due to promoter methylation …

Molecular pathological subclassification of mucinous adenocarcinoma of the colorectum

D Li, S Semba, M Wu, H Yokozaki - Pathology international, 2005 - Wiley Online Library
The purpose of the present report was to examine the possibility of molecular pathological
subtyping of mucinous adenocarcinomas (MAC) of the colorectum. Thirty‐five formalin‐fixed …

Molecular testing for microsatellite instability and its value in tumor characterization

M Kloor, M von Knebel Doeberitz… - Expert review of …, 2005 - Taylor & Francis
Molecular analysis of tumor tissue has become a rapidly expanding field in medical
research, exploiting the advantages of new technologies adapted to high-throughput …