The use of zinc in medicinal skin cream was mentioned in Egyptian papyri from 2000 BC (for
example, the Smith Papyrus), and zinc has apparently been used fairly steadily throughout …

Poly (ADP-ribose)(PAR) and the PAR polymerases (PARPs) that catalyze its synthesis from
donor nicotinamide adenine dinucleotide (NAD+) molecules have received considerable …

Abstract Poly (ADP-ribose) polymerases (PARPs) are involved in the regulation of many
cellular functions. Three consequences of the activation of PARP1, which is the main isoform …

The restoration of energy balance during ischemia is critical to cellular survival; however,
relatively little is known concerning the regulation of neuronal metabolic pathways in …

It is well established that tissue damage and functional outcome after experimental or
clinical stroke are shaped by biologic sex. We investigated the novel hypothesis that …

Poly (ADP-ribosyl) ation plays an important role in modulating the cellular response to
stress. The extent of poly (ADP-ribosyl) ation, chiefly via the activation of the poly (ADP …

DNA damage occurs in ischemia, excitotoxicity, inflammation, and other disorders that affect
the central nervous system (CNS). Extensive DNA damage triggers cell death and in the …

Astrocytes are essential for neuronal survival and function, neurogenesis, and neural repair.
Although astrocytes are more resistant than neurons to most stress conditions in vitro …

Poly (ADP-ribose) glycohydrolase (PARG) is a catabolic enzyme that cleaves ADP-ribose
polymers formed by members of the PARP family of enzymes. Despite its discovery and …

The use of chemical modifiers as radiosensitizers in combination with low-dose irradiation
may increase the therapeutic effect on cancer by overcoming a high apoptotic threshold …