The cholinergic hypothesis of decline in dementia, whereby deficits in learning, memory and
behavior are caused, at least in part, by decreased levels of acetylcholine (ACh) in the brain …

Dementia associated with probable Alzheimer's disease (AD) is one of the most common
types of dementia. Patients with AD often have cholinergic deficits in association with the …

Like acetylcholinesterase, butyrylcholinesterase (BChE) inactivates the neurotransmitter
acetylcholine (ACh) and is hence a viable therapeutic target in Alzheimer's disease, which is …

As presentes recomendações e sugestões para o" Tratamento da Doença de Alzheimer"
foram elaboradas por grupo de trabalho constituído por participantes da IV Reunião de …

In continuing research that led us to identify a new class of carbamate derivatives acting as
potent (Rampa et al. J. Med. Chem. 1998, 41, 3976) and long-lasting (Rampa et al. J. Med …

The purpose of this study was to investigate the effects of donepezil, a cholinergic agent, on
chronic cognitive impairment due to traumatic brain injury (TBI). Chronic patients underwent …

Acetylcholinesterase and butyrylcholinesterase activities emerge in association with
plaques and tangles in Alzheimer's disease. These pathological cholinesterases, with …

Alzheimer's disease is the most common form of neurodegenerative dementia and poses
considerable health challenges to both patients and their families. Rivastigmine is a …

Tacrine heterobivalent ligands were designed as novel and reversible inhibitors of
cholinesterases. On the basis of the investigation of the active site gorge topology of …

Objective Cholinesterase inhibitors improve cognitive functioning in Alzheimer disease (AD).
The authors studied, with functional magnetic resonance imaging (fMRI), the neural …