Drug-induced vascular injury in animals has been a topic of intense discussion and debate
in the toxicology, clinical, and regulatory arena for the past 25 years. A lack of understanding …

The aerodynamic particle sizer (APS) measures the size distributions of particles with
aerodynamic diameter between 0.5 and 20μm in real time. To provide accurate size …

We studied the variations caused by stress in lipoprotein lipase (LPL) activity, LPL-mRNA,
and local blood flow in LPL-rich tissues in the rat. Stress was produced by body …

When given during closed-chest resuscitation, cariporide (4-isopropyl-
methylsulfonylbenzoyl-guanidine methanesulfonate; a selective inhibitor of the Na+/H+ …

We studied the spatial distribution of the abnormal ventilation-perfusion (V̇a/Q̇) units in a
porcine model of acute pulmonary thromboembolism (APTE), using the fluorescent …

Vascular infusions of 15-μm-diameter microspheres are used to study pulmonary blood flow
distribution. The sites of microsphere lodging and their effects on microvascular perfusion …

High-resolution estimates of ventilation distribution in normal animals utilizing deposition of
fluorescent microsphere aerosol (FMS technique) demonstrate substantial ventilation …

Structural and functional maturation of a number of fetal organs and physiological systems
occurs in the immediate period prior to term, in association with the prepartum increase in …

Hypoxic pulmonary vasoconstriction (HPV) is known to affect regional pulmonary blood flow
distribution. It is unknown whether lungs with well-matched ventilation (V̇)/perfusion (Q̇) …

Background: When initiated in anemic hypoxia, hyperoxic ventilation (ventilation with pure
O2, FiO2 1.0, HV) reverses hypoxia-induced ECG-changes and enables survival for several …