Presenilin function and γ‐secretase activity
AL Brunkan, AM Goate - Journal of neurochemistry, 2005 - Wiley Online Library
Alzheimer's disease (AD) is the most common form of dementia and is characterized
pathologically by the accumulation of β‐amyloid (Aβ) plaques and neurofibrillary tangles in …
pathologically by the accumulation of β‐amyloid (Aβ) plaques and neurofibrillary tangles in …
Presenilin 2 familial Alzheimer's disease mutations result in partial loss of function and dramatic changes in Aβ 42/40 ratios
ES Walker, M Martinez, AL Brunkan… - Journal of …, 2005 - Wiley Online Library
Gene knockout studies in mice suggest that presenilin 1 (PS1) is the major γ‐secretase and
that it contributes disproportionately to amyloid β (Aβ) peptide generation from β‐amyloid …
that it contributes disproportionately to amyloid β (Aβ) peptide generation from β‐amyloid …
Familial Alzheimer's disease mutations inhibit γ‐secretase‐mediated liberation of β‐amyloid precursor protein carboxy‐terminal fragment
JC Wiley, M Hudson, KC Kanning… - Journal of …, 2005 - Wiley Online Library
Cleavage of the β‐secretase processed β‐amyloid precursor protein by γ‐secretase leads to
the extracellular release of Aβ42, the more amyloidogenic form of the β‐amyloid peptide …
the extracellular release of Aβ42, the more amyloidogenic form of the β‐amyloid peptide …
Increased tau phosphorylation on mitogen-activated protein kinase consensus sites and cognitive decline in transgenic models for Alzheimer's disease and FTDP-17 …
SL Lambourne, LA Sellers, TG Bush… - … and Cellular Biology, 2005 - Taylor & Francis
Abnormal tau phosphorylation occurs in several neurodegenerative disorders, including
Alzheimer's disease (AD) and frontotemporal dementia with Parkinsonism linked to …
Alzheimer's disease (AD) and frontotemporal dementia with Parkinsonism linked to …
Stimulation of G‐proteins in human control and Alzheimer's disease brain by FAD mutants of APP714–723: Implication of oxidative mechanisms
E Karelson, S Fernaeus, K Reis… - Journal of …, 2005 - Wiley Online Library
We report the effects of amyloid precursor protein (APP) fragment 714–723 (APP714–723;
peptide P1) and its V717F and V717G mutants (peptides P2 and P3, respectively) on G …
peptide P1) and its V717F and V717G mutants (peptides P2 and P3, respectively) on G …